1 to 1 of 1 Permanent Validation Jobs in Harrogate

ADCs) and biomarkers, using liquid chromatography-mass spectrometry (LC/MS) and high-resolution mass spectrometry (HRMS). These methods will be transferred to validation and used in support of regulatory submissions. Key Responsibilities: Develop, optimize, and prepare LC/MS and HRMS methods for regulatory readiness, ensuring they meet … the required standards for validation and transfer. Perform method development for the bioanalysis of small molecules Perform both bottom-up and top-down method development for the bioanalysis of large molecules: Bottom-Up Method Development: Enzymatic digestion of proteins into peptides followed by LC/MS analysis for the identification … intact proteins and protein complexes using LC/MS to allow for detailed characterization of protein structure, including proteoforms and complex modifications. Collaborate with validation teams to ensure smooth method transfer and implementation. Troubleshoot and maintain LC/MS and HRMS instrumentation to ensure optimal performance. Stay current with advancements more »