Cambridge University Hospital NHS Foundation Trust
human inherited disorders Desirable Able to conduct Research and Development activities. Ability to carry out audits, incident investigations and root cause analysis. Experience of bioinformatics tools Experience in using interpretation frameworks for the analysis of genomic variants Additional Requirements Essential The ability to understand and behave at all times, towards more »
opportunity to make a significant impact on our mission. Role The Principal Scientist will play a pivotal role as the first internal full-time bioinformatics role, inheriting some existing infrastructure and potentially collaborating with contractors. The role will primarily be research-focused, analyzing all omic data produced by the company … mission. Work with bench scientists by guiding experimental workflows and quantitative measurement to ensure statistical rigor and help build data visualizations. Qualifications: PhD in bioinformatics, computational biology, system biology, or a related field. Minimum of 6 years of post-PhD life sciences research experience, of which at least 5 years … should have been spent doing bioinformatics, preferably in biotech or pharma. Proficiency in R or Python, and familiarity with workflow management tools such as snakemake or Nextflow. Basic proficiency with databases is expected. Experience with analysis of bulk and single-cell RNA-seq data and preferably with pooled CRISPR screens more »
approaches to identify predictive safety markers and build robust predictive models for safety assessment in drug development. Contribute to the design and implementation of bioinformatics pipelines for processing, quality control, and analysis of multi-omics data. Collaborate with experimental scientists to interpret omics data in the context of safety assessment … and provide actionable insights to guide decision-making in drug development. Stay abreast of the latest developments in bioinformatics, multi-omics, and predictive modelling, and apply cutting-edge methodologies to enhance predictive safety assessment capabilities. Requirements: A Ph.D. or equivalent experience in bioinformatics, computational biology, or a related field with … and metabolomics, with the potential for omics datatypes relevant to safety assessment. Proficiency in programming languages such as R or Python, and experience with bioinformatics tools and databases commonly used in omics data analysis. Strong understanding of statistical methods, machine learning approaches, and data visualization techniques for omics data analysis more »
