Bioinformatician - Genomics Innovation Unit
Job summary
The Genomics Innovation Unit (GIU) at Guy's and St. Thomas' NHS Trust is looking to grow its team strategically, adding a talented computational biologist to help us expand our capabilities and take on more projects simultaneously, while remaining nimble, dynamic, and effective. The primary project for this role will involve developing algorithms and implementing pipelines to analyse genomic and transcriptomic datasets towards the rapid detection of different types of cancer.
In addition, the GIU develops novel genomic diagnostic tests, and in the process innovates new experimental approaches. Sinch the experimental workflows are customised for each project, the computational workflows also have to be tailored to suit each application. GIU projects typically involve genomic sequencing of patient samples, including but not limited to Oxford Nanopore and Illumina sequencing. This part of the role will involve developing algorithms and writing software to convert raw sequencing data into diagnoses, using in-house code and off-the shelf components. Another important aspect of this job will be providing bioinformatic support for our many collaborations with academics from King's College London, and several NHS Trusts. Finally, the GIU is making strides into using machine learning for genomic applications, for which we have access to in-house and HPC GPUs. There is room within this role to pursue cutting-edge projects applying deep learning to genomic and proteomic data.
Main duties of the job
The GIU develops novel genomic diagnostic tests, and in the process innovates new experimental approaches. Since the experimental workflows are customised for each project, the computational workflows also have to be tailored to suit each application. Experimentally, GIU projects typically involve genomic sequencing of patient samples, including but not limited to Oxford Nanopore and Illumina sequencing. This part of the role will primarily involve developing algorithms and writing software to convert raw sequencing data into diagnoses, using in-house code and off-the shelf components. Another important aspect of this job will be providing bioinformatic support for our many collaborations with academics from King's College London, and several NHS Trusts. Finally, the GIU is making strides into using machine learning for genomic applications, for which we have access to in-house and HPC GPUs. There is room within this role to pursue cutting-edge projects applying deep learning to genomic and proteomic data.
About us
The Genomics Innovation Unit (GIU) at Guy's and St. Thomas' NHS Trust is a unique and exciting technology incubator within the NHS. The GIU develops novel genomic diagnostic tests for cancer and rare diseases, applying cutting-edge molecular biology and computational techniques in the process. Our research is application-driven, forming the vital link between translational research and clinical implementation, and culminating in tangible improvements to patient care. Our work takes genomic biomarkers through the life cycle of diagnostic test development, from proof-of-concept studies through to validation and accreditation. In the short time since the GIU's creation we have developed several testing approaches which focus on delivering more personalised treatments for patients.
Job description
Job responsibilities
You must be comfortable working in a multidisciplinary environment, have excellent communication skills, and be comfortable working independently. The role calls for a detail-oriented and highly motivated individual with experience in python programming, nextflow workflows, and github and the ability to deliver to time and target. Eligible candidates will have a Masters or PhD in Bioinformatics or Computational Biology, with proven programming experience in Python and Nextflow. An ability to work independently and within strict timelines is essential.
- Devising algorithms and writing software to convert raw data (typically genomic sequencing data) into diagnoses
- Performing ad-hoc bioinformatic analyses as required for the GIU and collaborators
- Presenting results at internal and external meetings and conferences
- Keeping up to date with the latest research literature towards finding or evaluating new projects
- Helping to write scientific publications
Person Specification
Experience
- Experience with version control systems such as Github
Qualifications
- Educated to a Masters level in bioinformatics, computer science, or computational biology
- Educated to a PhD level in bioinformatics, computer science, or computational biology
Experience
- Nextflow pipeline development experience
Experience
- At least 2 years of Python programming experience
Experience
- Experience with SQL or other database languages
Experience
- Software Development experience, especially with containerised software in Docker and/or Singularity
Experience
- Experience implementing deep neural networks in PyTorch or TensorFlow
Experience
- Experience analysing Genomic / Transcriptomic datasets
Skills
- Ability to develop computational approaches to analyse data to solve problems
Skills
- Strong mathematical ability, especially in linear algebra and calculus
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Certificate of Sponsorship
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website.
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants.
Employer details
Employer name
Guy's and St Thomas' NHS Foundation Trust
Address
10th Floor Tower Wing, Guy's Hospital
Great Maze Pond
London
SE19RT
https://www.guysandstthomas.nhs.uk/careers/careers.aspx
- Company
- Guy's and St Thomas' NHS Foundation Trust
- Location
- London, United Kingdom SE19RT
- Employment Type
- Fixed-Term
- Salary
- £51488.00 - £57802.00 a year
- Posted
- Company
- Guy's and St Thomas' NHS Foundation Trust
- Location
- London, United Kingdom SE19RT
- Employment Type
- Fixed-Term
- Salary
- £51488.00 - £57802.00 a year
- Posted